Lactation A minimum of a person Demise was described in the nursing infant who was subjected to significant amounts of morphine in breast milk since the mother was an extremely-quick metabolizer of codeine.
you should know this medication may perhaps make you drowsy. Will not travel a car or function machinery until eventually you know how this medication has an effect on you.
Promethazine has an elimination 50 %-life of 10-fourteen several hours, with excretion of metabolites showing up from the urine and feces. The sulfoxides of promethazine and N-demethylpromethazine are definitely the predominant metabolites showing up inside the urine.
Suggest sufferers not to enhance the dose or dosing frequency of Promethazine with Codeine Oral Answer because major adverse occasions for instance respiratory melancholy may come about with overdosage [see Warnings and Precautions (five.
Make certain you know the way to just take this product or service and what other medication you ought to avoid taking with it. See also Drug Interactions section. Get health care assistance instantly if any of such really really serious side effects take place: gradual/shallow breathing, strange lightheadedness, intense drowsiness/dizziness, problem waking up.
When codeine is utilised for some time, it may well grow to be practice-forming, causing mental or Actual physical dependence. Having said that, Individuals who have continuing agony should not Allow the panic of dependence retain them from applying narcotics To ease their ache. Psychological dependence (habit) is not going to manifest when narcotics are used for this function.
The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complex.
Codeine and hydrocodone can also interact with sedative prescription drugs, Specially benzodiazepines. Mixing these medicines can have an impact on respiration and can likely be deadly. This combination was responsible for Practically fourteen% of overdose deaths involving opioids in 2021.
The concomitant utilization of anticholinergic medicines with Promethazine with Codeine Oral Resolution could maximize hazard of urinary retention and/or critical constipation, which may lead to paralytic ileus [seeWARNINGS AND PRECAUTIONS (five.
Procedure of toxicity depends on both equally the symptoms and degree of intoxication. Toxicity will involve symptomatic remedy (ie, enema for constipation) and definitive reversal Together with the opioid antagonist naloxone for life-threatening adverse consequences like respiratory depression.
Tell your doctor If the cough lasts, returns, or receives worse immediately after 7 times or whether it is accompanied by headache that doesn't disappear, fever, intense sore throat, or rash.
Codeine has low plasma protein binding with about seven to twenty five% of codeine sure to plasma proteins. Codeine passes the blood Mind barrier along with the placental barrier. Little quantities of codeine and its metabolite, morphine, are transferred to human breast milk.
Use of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with Promethazine with Codeine Oral Solution involves mindful thought of the results over the father or mother drug, codeine, and the Promethazine codeine syrup Lively metabolite, morphine.
Working with Alcoholic beverages or tobacco with specific medicines may cause interactions to arise. The subsequent interactions are chosen on the basis in their prospective importance and so are not essentially all-inclusive.